https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7232 Sat 24 Mar 2018 08:40:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9573 Sat 24 Mar 2018 08:34:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24492 -1 Mn, and this correlated with an increase in TH phosphorylation at serines 40, 31 and 19. However, in the striatum at PND70, a time by which Mn levels were no longer elevated, there was a dose dependent decrease in TH protein levels, reaching significance at 20 mg kg^-1 Mn, and this correlated with TH phosphorylation at Ser40 and Ser19. There was however a significant increase in phosphorylation of TH at serine 31 at 20 mg kg^-1 Mn, which did not correlate with TH protein levels. Taken together our findings suggest that neonatal Mn exposure can have both short-term and long-term effects on the regulation of TH in the striatal dopaminergic system.]]> Fri 22 Apr 2022 10:22:04 AEST ]]>